@conference {,
	title = {Towards Automated Comprehension and Alignment of Cardiac Models at the System Invariant Level},
	booktitle = {CSBio{\textquoteright}20: Proceedings of the Eleventh International Conference on Computational Systems-Biology and Bioinformatics},
	year = {2020},
	author = {Huang, Samuel and Diep, Madeline and Jang, Kuk and Cherry, Elizabeth M and Fenton, Flavio H and Cleaveland, Rance and Lindvall, Mikael and Mangharam, Rahul and Porter, Adam}
}
@article {,
	title = {Probabilistic reachability for multi-parameter bifurcation analysis of cardiac alternans},
	journal = {Theoretical Computer Science},
	volume = {765},
	year = {2019},
	pages = {158{\textendash}169},
	author = {Islam, Md Ariful and Cleaveland, Rance and Fenton, Flavio H and Grosu, Radu and Jones, Paul L and Smolka, Scott A}
}
@article {,
	title = {Mechanism for amplitude alternans in electrocardiograms and the initiation of spatiotemporal chaos},
	journal = {Physical Review Letters},
	volume = {118},
	year = {2017},
	pages = {168101},
	abstract = {<p>It is widely believed that one major life-threatening transition to chaotic fibrillation occurs via spiral-wave breakup that is preceded by spatiotemporal dispersion of refractoriness due to alternations in the duration of the cardiac action potential (AP). However, recent clinical and experimental evidence suggests that other characteristics of the AP may contribute to, and perhaps drive, this dangerous dynamical instability. To identify the relative roles of AP characteristics, we performed experiments in rabbit hearts under conditions to minimize AP duration dynamics which unmasked pronounced AP amplitude alternans just before the onset of fibrillation. We used a simplified ionic cell model to derive a return map and a stability condition that elucidates a novel underlying mechanism for AP alternans and spiral breakup. We found that inactivation of the sodium current is key to developing amplitude alternans and is directly connected to conduction block and initiation of arrhythmias. Simulations in 2D where AP amplitude alternation led to turbulence confirm our hypothesis.</p>
},
	author = {Chen, Diandian Diana and Gray, Richard A and Uzelac, Ilija and Herndon, Conner and Fenton, Flavio H}
}
